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Hep C Treatment: Comparing the Pegylated Interferons
Learn about the facts on pegylated interferon alfa-2a and pegylated interferon alfa-2b, the standard treatment for chronic Hepatitis C. Comparing and contrasting the pegylated interferons may help better explain a physician’s preference or indifference between the two when treating their...

Vertex's Advanced Trial Could Change HCV Treatment
Hundreds of non-responders to interferon-ribavirin combination therapy will be enrolled in a late stage clinical trial for Vertex's telaprevir....

Silymarin Improves Quality of Life During Hepatitis C Treatment
Although a large-scale study concluded long-term interferon therapy to be ineffectual for Hepatitis C management, it demonstrated improvements in quality of life for participants supplementing with silymarin....

Damage Scores for Liver Biopsy

Less Than Less Than

Greater Than More Than

HISTOLOGY ACTIVITY INDEX (HAI - Knodell Score)

 
Periportal ± Bridging Necrosis Score Intralobular Degeneration and Focal Necrosis Score Portal Inflammation Score Fibrosis Score
None 0 None 0 No portal inflammation 0 No fibrosis 0
Mild piecemeal necrosis 1 Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in 1/3 of lobules or nodules) 1 Mild (sprinkling of inflammatory cells in Less Than 1/3 of portal tracts) 1 Fibrous portal expansion 1
Moderate piecemeal necrosis (involves      Less Than 50% of the circumference of most portal tracts) 3 Moderate (involvement of 1/3-2/3 of lobules or nodules) 3 Moderate (increased inflammatory cells in 1/3-2/3 of portal tracts) 3 Bridging Fibrosis (portal-portal or portal-central linkage) 3
Marked piecemeal necrosis (involves     Greater Than 50% of the circumference of most portal tracts) 4 Marked (involvement of Greater Than 2/3 of lobules or nodules) 4 Marked (dense packing of inflammatory cells in Greater Than 2/3 of portal tracts) 4 Cirrhosis 4
Moderate piecemeal necrosis plus bridging necrosis 5

ReferenceKnodell RG, et al. 
Marked piecemeal necrosis plus bridging necrosis 6
Multilobular necrosis 10
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Updated 28 Aug 2008